Synthesis and hypoglycemic activity of quinoxaline derivatives
نویسندگان
چکیده
In this study, a new series of quinoxalinone derivatives (5a–5p, 6a–6n) was designed and its hypoglycemic activity evaluated. The results showed that compounds 5i 6b exhibited stronger effects than the lead were comparable to positive control Pioglitazone. may exert by alleviating cellular OS modulating interactions among GLUT4, SGLT2, GLUT1 proteins. compound better 5i, found bind for most screening targets. summary, is potential with hypoglycaemic activity.3
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ژورنال
عنوان ژورنال: Frontiers in Chemistry
سال: 2023
ISSN: ['2296-2646']
DOI: https://doi.org/10.3389/fchem.2023.1197124